MFN2 Polyclonal AntibodyE-AB-32025
Product Type: Antibody
Descritpion: This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.
Research Areas: Cancer, Cell Biology, Metabolism, Neuroscience, Signal transduction, Tags & Cell Markers
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human Mfn2.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 86kDa
Tissue Specificity/Positive Control: Ubiquitous; expressed at low level. Highly expressed in heart and kidney.
Cellular Localization: Mitochondrion outer membrane. Colocalizes with BAX during apoptosis.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-mfn2_polyclonal_antibody-28350.html
Manual Link: https://www.elabscience.com/viewpdf-28350-elabscience-E-AB-32025.PDF