Product Type: Antibody
Descritpion: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Research Areas: Cancer, Cell Biology, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000
Size: 200 uL
Immunogen: Synthesized peptide derived from the C-terminal region of human Nrf2
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 75-100kDa
Tissue Specificity/Positive Control: Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.
Cellular Localization: Cytoplasm>cytosol. Nucleus. Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
Storage: Store at -20C. Avoid freeze / thaw cycles.