p53R2 Polyclonal AntibodyE-AB-32477
Product Type: Antibody
Descritpion: Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Metabolism
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:40000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human p53R2.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 41kDa
Tissue Specificity/Positive Control: Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma.
Cellular Localization: Cytoplasm. Nucleus. Translocates from cytoplasm to nucleus in response to DNA damage.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-p53r2_polyclonal_antibody-28802.html
Manual Link: https://www.elabscience.com/viewpdf-28802-elabscience-E-AB-32477.PDF