p70 S6 kinase alpha Polyclonal AntibodyE-AB-32482
Product Type: Antibody
Descritpion: P70 S6 Kinase alpha is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and contains 2 non-identical kinase catalytic domains. It phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein is activated by serine/threonine phosphorylation and protein kinase C and inactivated by type 2A phosphatase. Activation leads to an increase in protein synthesis and cell proliferation. Overexpression of this kinase is involved in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000
Size: 200 uL
Immunogen: Synthesized peptide derived from human p70 Ser6 kinase ? around the non-phosphorylation site of Thr229.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 59kDa
Tissue Specificity/Positive Control: Widely expressed.
Cellular Localization: Cytoplasm; Nucleus. Cytoplasm and Cell junction>synapse>synaptosome. Mitochondrion outer membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-p70_s6_kinase_alpha_polyclonal_antibody-28807.html
Manual Link: https://www.elabscience.com/viewpdf-28807-elabscience-E-AB-32482.PDF