PARP2 Polyclonal AntibodyE-AB-32507
Product Type: Antibody
Descritpion: This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.PARP2 (Poly(ADP-Ribose) Polymerase 2) is a Protein Coding gene. Diseases associated with PARP2 include Arts Syndrome. Among its related pathways are DNA Double-Strand Break Repair and Nucleotide excision repair. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP1.
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:40000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human PARP-2
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 66kDa
Tissue Specificity/Positive Control: Widely expressed, mainly in actively dividing tissues. The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected in kidney, liver, lung, placenta, ovary and spleen; levels are low in leukocytes, colon, small intestine, prostate and thymus.
Cellular Localization: Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-parp2_polyclonal_antibody-28832.html
Manual Link: https://www.elabscience.com/viewpdf-28832-elabscience-E-AB-32507.PDF