PDE4C Polyclonal Antibody

PDE4C Polyclonal Antibody

E-AB-32527

Regular price $399.00 $349.00 You Pay

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.PDE4C (Phosphodiesterase 4C) is a Protein Coding gene. Diseases associated with PDE4C include Ocular Hypotension. Among its related pathways are GABAergic synapse and Sweet Taste Signaling. GO annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and 3,5-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE4D.
Research Areas: Signal transduction
Applications: WB,ELISA
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:5000
Size: 200 uL
Concentration: 1mg/mL
Swissprot: Q08493
Gene Accession:
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from the Internal region of human PDE4C
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 80kDa
Tissue Specificity/Positive Control: Expressed in various tissues but not in cells of the immune system.
Cellular Localization: Cytosol,Extracellular region or secreted,extracellular space,Other locations:cilium
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-pde4c_polyclonal_antibody-28852.html
Manual Link: https://www.elabscience.com/viewpdf-28852-elabscience-E-AB-32527.PDF