PDK1 Polyclonal AntibodyE-AB-32534
Product Type: Antibody
Descritpion: Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. PDK1 (Pyruvate Dehydrogenase Kinase 1) is a Protein Coding gene. Diseases associated with PDK1 include Chronic Mountain Sickness. Among its related pathways are Development EPO-induced Jak-STAT pathway and PI3K-AKT-mTOR signaling pathway and therapeutic opportunities. GO annotations related to this gene include protein kinase activity and pyruvate dehydrogenase (acetyl-transferring) kinase activity. An important paralog of this gene is PDK2.
Research Areas: Cancer, Metabolism, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:5000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human PDK1
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 49kDa
Tissue Specificity/Positive Control: Expressed predominantly in the heart.
Cellular Localization: Mitochondrion matrix.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-pdk1_polyclonal_antibody-28859.html
Manual Link: https://www.elabscience.com/viewpdf-28859-elabscience-E-AB-32534.PDF