PDLIM5 Polyclonal AntibodyE-AB-32537
Product Type: Antibody
Descritpion: May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses.
Research Areas: Neuroscience, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:10000
Size: 200 uL
Immunogen: Synthesized peptide derived from human PDLIM5 around the non-phosphorylation site of Y251.
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 64kDa
Tissue Specificity/Positive Control: Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.
Cellular Localization: Cell junction>synapse>postsynaptic cell membrane>postsynaptic density. Cell junction>synapse>synaptosome. Cytoplasm. Detected both at presynaptic and postsynaptic sites.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-pdlim5_polyclonal_antibody-28862.html
Manual Link: https://www.elabscience.com/viewpdf-28862-elabscience-E-AB-32537.PDF