PPHLN1 Polyclonal AntibodyE-AB-32545
Product Type: Antibody
Descritpion: The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.PPHLN1 (Periphilin 1) is a Protein Coding gene. Diseases associated with PPHLN1 include Intrahepatic Cholangiocarcinoma. GO annotations related to this gene include poly(A) RNA binding.
Research Areas: Cell Biology
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human Periphilin 1
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 53kDa
Tissue Specificity/Positive Control: Ubiquitous.
Cellular Localization: Nucleus. Cytoplasm. In undifferentiated keratinocytes expressed in speckle-type nuclear granules and at the nuclear membrane, but in the differentiated keratinocytes colocalized with periplakin at the cell periphery and at cell-cell junctions.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-pphln1_polyclonal_antibody-28870.html
Manual Link: https://www.elabscience.com/viewpdf-28870-elabscience-E-AB-32545.PDF