PERK Polyclonal AntibodyE-AB-32546
Product Type: Antibody
Descritpion: Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1.
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Metabolism
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000
Size: 200 uL
Immunogen: Synthesized peptide derived from the N-terminal region of human PERK
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 125kDa
Tissue Specificity/Positive Control: Ubiquitous. A high level expression is seen in secretory tissues.
Cellular Localization: Endoplasmic reticulum membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-perk_polyclonal_antibody-28871.html
Manual Link: https://www.elabscience.com/viewpdf-28871-elabscience-E-AB-32546.PDF