PEX5 Polyclonal AntibodyE-AB-32552
Product Type: Antibody
Descritpion: The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.
Research Areas: Cancer, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:40000
Size: 200 uL
Immunogen: Synthesized peptide derived from the C-terminal region of human Peroxin 5
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 71kDa
Tissue Specificity/Positive Control: Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Cellular Localization: Cytoplasm. Peroxisome membrane. Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane through a docking factor.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-pex5_polyclonal_antibody-28877.html
Manual Link: https://www.elabscience.com/viewpdf-28877-elabscience-E-AB-32552.PDF