Product Type: Antibody
Descritpion: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
Research Areas: Cancer, Metabolism, Immunology, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:50-1:200, ELISA 1:40000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human PI 3-kinase p85?.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 84kDa
Tissue Specificity/Positive Control: Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
Cellular Localization: Cytosol,Endoplasmic reticulum,perinuclear endoplasmic reticulum membrane,Nucleus,Plasma Membrane,Other locations:cell-cell junction,cis-Golgi network,cytoplasm,membrane,phosphatidylinositol 3-kinase complex,phosphatidylinositol 3-kinase complex, class IA,protein complex
Storage: Store at -20C. Avoid freeze / thaw cycles.