PNN Polyclonal AntibodyE-AB-32587
Product Type: Antibody
Descritpion: Pinin is a desmosomal associated protein involved with the maintenance of cell to cell adhesion of the epithelium. Pinin is a widespread protein and has been shown to play an important role in cell adhesion through its interaction with nuclear complexes. Pinin is also involved in pre-mRNA splicing through its interactions with a C-terminal RS domain of Cyclophilin G, a Moca type nuclear cyclophilin. Pinin becomes nuclear during the early stages of embryonic development and remains so throughout the entire period. Defects or lack of Pinin can be lethal at perinatal stages and causes defects in the cardiac outflow tract, axial skeleton, palate and dorsal dermis.
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:20000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human Pinin
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 82kDa
Tissue Specificity/Positive Control: Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors.
Cellular Localization: Nucleus speckle. Cell junction>desmosome. Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-pnn_polyclonal_antibody-28912.html
Manual Link: https://www.elabscience.com/viewpdf-28912-elabscience-E-AB-32587.PDF