EIF2AK2 Polyclonal AntibodyE-AB-32617
Product Type: Antibody
Descritpion: Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.
Research Areas: Cancer, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000
Size: 200 uL
Immunogen: Synthesized peptide derived from human PKR around the non-phosphorylation site of T258.
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 62kDa
Tissue Specificity/Positive Control: Highly expressed in thymus, spleen and bone marrow compared to non-hematopoietic tissues such as small intestine, liver, or kidney tissues. Colocalizes with GSK3B and TAU in the Alzheimer disease (AD) brain. Elevated levels seen in breast and colon carcinomas,and which correlates with tumor progression and invasiveness or risk of progression.
Cellular Localization: Cytosol,Nucleus,Other locations:cytoplasm,membrane,perinuclear region of cytoplasm,ribosome
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-eif2ak2_polyclonal_antibody-28942.html
Manual Link: https://www.elabscience.com/viewpdf-28942-elabscience-E-AB-32617.PDF