POT1 Polyclonal AntibodyE-AB-32636
Product Type: Antibody
Descritpion: This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:10000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human POT1.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 71kDa
Tissue Specificity/Positive Control: Ubiquitous.
Cellular Localization: Nucleus. Chromosome>telomere. Colocalizes with telomeric DNA.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-pot1_polyclonal_antibody-28961.html
Manual Link: https://www.elabscience.com/viewpdf-28961-elabscience-E-AB-32636.PDF