PPM1L Polyclonal AntibodyE-AB-32642
Product Type: Antibody
Descritpion: The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene.PPM1L (Protein Phosphatase, Mg2+/Mn2+ Dependent 1L) is a Protein Coding gene. Among its related pathways are Development Dopamine D2 receptor transactivation of EGFR and MAPK Signaling: Oxidative Stress Pathway. GO annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is ILKAP.
Research Areas: Cancer, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:10000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human PP2C?
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 41kDa
Tissue Specificity/Positive Control: Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas.
Cellular Localization: Membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-ppm1l_polyclonal_antibody-28967.html
Manual Link: https://www.elabscience.com/viewpdf-28967-elabscience-E-AB-32642.PDF