Product Type: Antibody
Descritpion: Peroxisome proliferator-activated receptor alpha (PPARA) is a ligand-activated transcription factor that belongs to the PPAR nuclear receptor superfamily. PPARA is essential in the modulation of lipid transport and metabolism, mainly through activating mitochondrial and peroxisomal fatty acid ?-oxidation pathways. In addition, PPARA seems to decrease inflammation mainly through direct interaction with NF-?B, causing inhibition of its signaling pathway or reducing the activated levels of NF-?B and subsequent inflammation. Furthermore, PPARA was implicated in the attenuation of oxidative stress in alcoholic liver disease when treated with polyenephosphatidylcholine through downregulation of ROS-generating enzymes such as ethanol-inducible cytochrome P450 2E1 (CYP2E1), acyl-CoA oxidase, and NADPH oxidase.
Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
Recommended Dilutions: WB 1:500-2000, IHC 1:50-300, IF 1:50-1:200, ELISA 1:10000-20000
Size: 200 uL
Immunogen: Synthesized peptide derived from human PPAR-? around the non-phosphorylation site of Ser21.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 52kDa
Tissue Specificity/Positive Control: Skeletal muscle, liver, heart and kidney.
Cellular Localization: Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.