RAB11FIP2 Polyclonal AntibodyE-AB-32709
Product Type: Antibody
Descritpion: A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.
Research Areas: Cancer, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:10000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human Rab11-FIP2
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 58kDa
Tissue Specificity/Positive Control:
Cellular Localization: Cell membrane. Recycling endosome membrane. Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-rab11fip2_polyclonal_antibody-29034.html
Manual Link: https://www.elabscience.com/viewpdf-29034-elabscience-E-AB-32709.PDF