RAC1/2/3/CDC42 Polyclonal AntibodyE-AB-32716
Product Type: Antibody
Descritpion: The protein encoded by RAC1 is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.The RAC1 P29S mutation is the third most common protein-coding hotspot mutation in melanomas, ocurring in 4-9%.
RAC2 (Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2)) is a Protein Coding gene. Diseases associated with RAC2 include Neutrophil Immunodeficiency Syndrome and Retinitis Pigmentosa 47. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and Bisphosphonate Pathway, Pharmacodynamics. An important paralog of this gene is RAC1.
RAC3 (Ras-Related C3 Botulinum Toxin Substrate 3 (Rho Family, Small GTP Binding Protein Rac3)) is a Protein Coding gene. Among its related pathways are Bisphosphonate Pathway, Pharmacodynamics and GPCR Pathway. An important paralog of this gene is RAC1.
CDC42 (Cell Division Cycle 42) is a Protein Coding gene. Diseases associated with CDC42 include Takenouchi-Kosaki Syndrome and Wiskott-Aldrich Syndrome. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and Bisphosphonate Pathway, Pharmacodynamics. An important paralog of this gene is RAC1.
Research Areas: Cancer, Immunology, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000
Size: 200 uL
Immunogen: Synthesized peptide derived from human Rac1/2/3/CDC42 around the non-phosphorylation site of Ser71.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 21kDa
Tissue Specificity/Positive Control: RAC1 is Isoform B is predominantly identified in skin and epithelial tissues from the intestinal tract. Its expression is elevated in colorectal tumors at various stages of neoplastic progression, as compared to their respective adjacent tissues.RAC2 isHematopoietic specific.RAC2 is Highest levels in brain, also detected in heart, placenta and pancreas.
Cellular Localization: Cytoskeleton,microtubule organizing center,mitotic spindle,spindle midzone,Cytosol,Endoplasmic reticulum,endoplasmic reticulum membrane,Extracellular region or secreted,extracellular exosome,Golgi apparatus,Golgi membrane,Golgi transport complex,Plasma Membrane,leading edge membrane,plasma membrane,Other locations:apical part of cell,cell-cell junction,cytoplasm,cytoplasmic ribonucleoprotein granule,dendritic spine,filopodium,focal adhesion,membrane,midbody,myelin sheath,neuron projection,neuronal cell body,phagocytic vesicle,protein complex,secretory granule,storage vacuole
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-rac1_2_3_cdc42_polyclonal_antibody-29041.html
Manual Link: https://www.elabscience.com/viewpdf-29041-elabscience-E-AB-32716.PDF