RHO Polyclonal AntibodyE-AB-32788
Product Type: Antibody
Descritpion: Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness.RHO (Rhodopsin) is a Protein Coding gene. Diseases associated with RHO include Night Blindness, Congenital Stationary, Autosomal Dominant 1 and Retinitis Pigmentosa 4, Autosomal Dominant Or Recessive. Among its related pathways are the visual cycle I (vertebrates) and Phototransduction. GO annotations related to this gene include G-protein coupled receptor activity and photoreceptor activity. An important paralog of this gene is OPN1SW.
Research Areas: Cancer, Neuroscience, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
Size: 200 uL
Immunogen: Synthesized peptide derived from human Rhodopsin around the non-phosphorylation site of S334.
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 39kDa
Tissue Specificity/Positive Control: Rod shaped photoreceptor cells which mediates vision in dim light.
Cellular Localization: Membrane. Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to the rod outer segment (OS) photosensory cilia.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-rho_polyclonal_antibody-29113.html
Manual Link: https://www.elabscience.com/viewpdf-29113-elabscience-E-AB-32788.PDF