RPL7 Polyclonal AntibodyE-AB-32805
Product Type: Antibody
Descritpion: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. RPL7 (Ribosomal Protein L7) is a Protein Coding gene. Diseases associated with RPL7 include Collagen Disease and Systemic Lupus Erythematosus. Among its related pathways are Viral mRNA Translation and rRNA processing in the nucleus and cytosol. GO annotations related to this gene include poly(A) RNA binding and RNA binding. An important paralog of this gene is RPL7L1.
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Immunology
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
Size: 200 uL
Immunogen: Synthesized peptide derived from the C-terminal region of human Ribosomal Protein L7
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 29kDa
Tissue Specificity/Positive Control:
Cellular Localization: Cytosolic large ribosomal subunit,Extracellular region or secreted,extracellular exosome,Nucleus,nucleolus,Other locations:cytoplasm,focal adhesion,intracellular ribonucleoprotein complex,membrane
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-rpl7_polyclonal_antibody-29130.html
Manual Link: https://www.elabscience.com/viewpdf-29130-elabscience-E-AB-32805.PDF