Product Type: Antibody
Descritpion: This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA.SF3B4 (Splicing Factor 3b Subunit 4) is a Protein Coding gene. Diseases associated with SF3B4 include Acrofacial Dysostosis 1, Nager Type and Acrofacial Dysostosis Syndrome Of Rodriguez. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and nucleotide binding.
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human SAP 49
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 44kDa
Tissue Specificity/Positive Control:
Cellular Localization: Nucleus,nucleoplasm,spliceosomal complex,U12-type spliceosomal complex
Storage: Store at -20C. Avoid freeze / thaw cycles.