SERPINB4 Polyclonal AntibodyE-AB-32855
Product Type: Antibody
Descritpion: The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. SERPINB4 (Serpin Family B Member 4) is a Protein Coding gene. Diseases associated with SERPINB4 include Squamous Cell Carcinoma and Chromosome 18Q Deletion Syndrome. Among its related pathways are Amoebiasis. GO annotations related to this gene include enzyme binding and protease binding. An important paralog of this gene is SERPINB3.
Research Areas: Cancer, Cell Biology, Immunology
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:5000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human SCCA2
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 45kDa
Tissue Specificity/Positive Control: Squamous cells.
Cellular Localization: Cytoplasm. Seems to also be secreted in plasma by cancerous cells but at a low level.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-serpinb4_polyclonal_antibody-29180.html
Manual Link: https://www.elabscience.com/viewpdf-29180-elabscience-E-AB-32855.PDF