SEPT6 Polyclonal AntibodyE-AB-32874
Product Type: Antibody
Descritpion: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. SEPT6 (Septin 6) is a Protein Coding gene. Diseases associated with SEPT6 include Sexual Disorder. Among its related pathways are Bacterial invasion of epithelial cells. GO annotations related to this gene include GTP binding. An important paralog of this gene is SEPT11.
Research Areas: Cell Biology, Microbiology
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human Septin 6
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 50kDa
Tissue Specificity/Positive Control: Widely expressed.
Cellular Localization: Cytoplasm. Cytoplasm>cytoskeleton>spindle. Chromosome>centromere>kinetochore. Cleavage furrow. Midbody. In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-sept6_polyclonal_antibody-29199.html
Manual Link: https://www.elabscience.com/viewpdf-29199-elabscience-E-AB-32874.PDF