ATP2A1 Polyclonal AntibodyE-AB-32877
Product Type: Antibody
Descritpion: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms.
Research Areas: Cancer, Cardiovascular, Metabolism, Signal transduction, Tags & Cell Markers
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human SERCA1
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 110kDa
Tissue Specificity/Positive Control: Skeletal muscle, fast twitch muscle (type II) fibers.
Cellular Localization: Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-atp2a1_polyclonal_antibody-29202.html
Manual Link: https://www.elabscience.com/viewpdf-29202-elabscience-E-AB-32877.PDF