STAT2 Polyclonal Antibody
STAT2 Polyclonal Antibody

STAT2 Polyclonal Antibody

E-AB-33322

Regular price $399.00 $349.00 You Pay

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal transduction
Applications: WB,IHC-p,ELISA
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-300, ELISA 1:10000
Size: 200 uL
Concentration: 1mg/mL
Swissprot: P52630
Gene Accession:
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from human Stat2 around the non-phosphorylation site of Tyr631.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 98kDa
Tissue Specificity/Positive Control:
Cellular Localization: Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-stat2_polyclonal_antibody-29647.html
Manual Link: https://www.elabscience.com/viewpdf-29647-elabscience-E-AB-33322.PDF