Product Type: Antibody
Descritpion: Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-300, ELISA 1:10000
Size: 200 uL
Immunogen: Synthesized peptide derived from human Stat2 around the non-phosphorylation site of Tyr631.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 98kDa
Tissue Specificity/Positive Control:
Cellular Localization: Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
Storage: Store at -20C. Avoid freeze / thaw cycles.