Product Type: Antibody
Descritpion: This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
Research Areas: Neuroscience
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-300, ELISA 1:10000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human APLP-1
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 72kDa
Tissue Specificity/Positive Control: Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD).
Cellular Localization: Cell membrane and Cytoplasm. C-terminally processed in the Golgi complex.
Storage: Store at -20C. Avoid freeze / thaw cycles.