UHRF1 Polyclonal Antibody

UHRF1 Polyclonal Antibody

E-AB-33336

Regular price $399.00 $349.00 You Pay

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Applications: WB,ELISA
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:40000
Size: 200 uL
Concentration: 1mg/mL
Swissprot: Q96T88
Gene Accession:
Reactivity: Human
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from the Internal region of human UHRF1.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 90kDa
Tissue Specificity/Positive Control: Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.
Cellular Localization: Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-uhrf1_polyclonal_antibody-29661.html
Manual Link: https://www.elabscience.com/viewpdf-29661-elabscience-E-AB-33336.PDF