Product Type: Antibody
Descritpion: This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants.TRIM68 (Tripartite Motif Containing 68) is a Protein Coding gene. Diseases associated with TRIM68 include Prostate Cancer. Among its related pathways are Interferon gamma signaling and Innate Immune System. GO annotations related to this gene include ligase activity and androgen receptor binding. An important paralog of this gene is TRIM21.
Research Areas: Immunology
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-300, ELISA 1:40000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human SS-56.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 56kDa
Tissue Specificity/Positive Control: Widely expressed. Expressed at high levels in prostate cancer cell lines. Up-regulation could be restricted to androgen-dependent cells.
Cellular Localization: Cytoplasm>perinuclear region. Nucleus. Colocalized with AR in nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.