CASP10 Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-AMC and Asp-Glu-Val-Asp-AMC.Isoform C is proteolytically inactive.
Research Areas: Cancer, Cell Biology, Metabolism
Applications: WB,ELISA
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:40000
Size: 200 uL
Concentration: 1mg/mL
Swissprot: Q92851
Gene Accession:
Reactivity: Human
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from the Internal region of human Caspase-10.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 59kDa
Tissue Specificity/Positive Control: Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
Cellular Localization: Cytosol,ripoptosome,Plasma Membrane,CD95 death-inducing signaling complex
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-casp10_polyclonal_antibody-29689.html
Manual Link: https://www.elabscience.com/viewpdf-29689-elabscience-E-AB-33364.PDF