CA4 Polyclonal AntibodyE-AB-33398
Product Type: Antibody
Descritpion: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport.
Research Areas: Neuroscience
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:20000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human CA IV.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 35kDa
Tissue Specificity/Positive Control: Expressed in the endothelium of the choriocapillaris in eyes (at protein level). Not expressed in the retinal epithelium at detectable levels.
Cellular Localization: Endoplasmic reticulum,rough endoplasmic reticulum,Extracellular region or secreted,extracellular exosome,Golgi apparatus,Golgi apparatus,trans-Golgi network,Plasma Membrane,anchored component of external side of plasma membrane,apical plasma membrane,brush border membrane,plasma membrane,Other locations:cell surface,endoplasmic reticulum-Golgi intermediate compartment,membrane,perinuclear region of cytoplasm,secretory granule membrane,transport vesicle membrane
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-ca4_polyclonal_antibody-29723.html
Manual Link: https://www.elabscience.com/viewpdf-29723-elabscience-E-AB-33398.PDF