c-FLIP Polyclonal AntibodyE-AB-33426
Product Type: Antibody
Descritpion: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Research Areas: Cancer, Cell Biology, Metabolism, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:20000
Size: 200 uL
Immunogen: Synthesized peptide derived from the N-terminal region of human c-FLIP.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 55kDa
Tissue Specificity/Positive Control: Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
Cellular Localization: Cytosol,ripoptosome,Plasma Membrane,CD95 death-inducing signaling complex,death-inducing signaling complex,Other locations:cytoplasm,membrane raft
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-c_flip_polyclonal_antibody-29751.html
Manual Link: https://www.elabscience.com/viewpdf-29751-elabscience-E-AB-33426.PDF