Product Type: Antibody
Descritpion: This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. APLN (Apelin) is a Protein Coding gene. Diseases associated with APLN include Syndrome Of Inappropriate Antidiuretic Hormone and Severe Pre-Eclampsia. Among its related pathways are Peptide ligand-binding receptors and Apelin signaling pathway. GO annotations related to this gene include receptor binding and G-protein coupled receptor binding.
Research Areas: Cancer, Cardiovascular, Metabolism, Neuroscience, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-300, ELISA 1:20000
Size: 200 uL
Immunogen: Synthesized peptide derived from the C-terminal region of human Apelin.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 9kDa
Tissue Specificity/Positive Control: Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain. Secreted by the mammary gland into the colostrum and the milk.
Cellular Localization: Secreted.
Storage: Store at -20C. Avoid freeze / thaw cycles.