Product Type: Antibody
Descritpion: This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Research Areas: Cancer, Cardiovascular, Metabolism, Immunology, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-300, ELISA 1:20000
Size: 200 uL
Immunogen: Synthesized peptide derived from the N-terminal region of human cPLA2.
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 85kDa
Tissue Specificity/Positive Control: Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.
Cellular Localization: Cytosol,Endoplasmic reticulum,endoplasmic reticulum membrane,Golgi apparatus,Golgi apparatus,Mitochondrion,mitochondrial inner membrane,Other locations:cytoplasmic vesicle,lipid droplet
Storage: Store at -20C. Avoid freeze / thaw cycles.