P63 Polyclonal Antibody
P63 Polyclonal Antibody

P63 Polyclonal Antibody

E-AB-33453

Regular price $399.00 $349.00 You Pay

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Applications: WB,IHC-p,ELISA
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-300, ELISA 1:20000
Size: 200 uL
Concentration: 1mg/mL
Swissprot: Q9H3D4
Gene Accession:
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from the N-terminal region of human p63.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 77kDa
Tissue Specificity/Positive Control: Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.
Cellular Localization: Nucleus
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-p63_polyclonal_antibody-29778.html
Manual Link: https://www.elabscience.com/viewpdf-29778-elabscience-E-AB-33453.PDF