Product Type: Antibody
Descritpion: SERPINB3(serpin peptidase inhibitor, clade B (ovalbumin), member 3), also known as SCCA1, increase in advancing stages of some cervical, lung, esophageal and head and neck cancers). Human chromosome position 18q21.3 contains a cluster of serpins, including a tandem duplication of the SCCA gene, plasminogen activator inhibitor type 2, and maspin. SCCA is transcribed by two nearly identical genes (SCCA1 and SCCA2), and is mainly produced as SCCA1. The human SCCA1 gene encodes a 390 amino acid protein that was originally isolated from a metastatic cervical squamous cell carcinoma.
Research Areas: Cancer, Cell Biology
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000-1:20000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human SCCA1/2.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 44kDa
Tissue Specificity/Positive Control: Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).
Cellular Localization: Cytoplasm. Seems to also be secreted in plasma by cancerous cells but at a low level.
Storage: Store at -20C. Avoid freeze / thaw cycles.