Product Type: Antibody
Descritpion: This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:50-1:200, ELISA 1:10000-1:20000
Size: 200 uL
Immunogen: Synthesized peptide derived from human EPAS-1 around the non-acetylation site of K385.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 96kDa
Tissue Specificity/Positive Control: Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells.
Cellular Localization: Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.