Product Type: Antibody
Descritpion: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Research Areas: Cancer, Cell Biology, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism
Recommended Dilutions: WB 1:500-2000, IHC 1:50-300, IF 1:50-1:200, ELISA 1:10000-20000
Size: 200 uL
Immunogen: Synthesized peptide derived from human Nrf2 around the non-acetylation site of K599.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 75-100kDa
Tissue Specificity/Positive Control: Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.
Cellular Localization: Cytoplasm>cytosol. Nucleus. Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
Storage: Store at -20C. Avoid freeze / thaw cycles.