Product Type: Antibody
Descritpion: The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.
Research Areas: Cancer, Cardiovascular, Metabolism
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300 ELISA 1:10000
Size: 200 uL
Immunogen: Synthesized peptide derived from the N-terminal region of human AAT.
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 47kDa
Tissue Specificity/Positive Control: Ubiquitous. Expressed in leukocytes and plasma.
Cellular Localization: Secreted. Endoplasmic reticulum. The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum and Secreted, extracellular space, extracellular matrix.
Storage: Store at -20C. Avoid freeze / thaw cycles.