VIPR1 Polyclonal AntibodyE-AB-33651
Product Type: Antibody
Descritpion: VIPR1 encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene.VIPR1 (Vasoactive Intestinal Peptide Receptor 1) is a Protein Coding gene. Diseases associated with VIPR1 include Holoprosencephaly-3 and Inflammatory Diarrhea. Among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and vasoactive intestinal polypeptide receptor activity. An important paralog of this gene is ADCYAP1R1.
Research Areas: Cancer, Cardiovascular, Neuroscience, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:10000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human VPAC1.
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 52kDa
Tissue Specificity/Positive Control: In lung, HT29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart, kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78, Jurkat and Tsup-1, but not in the T-cell lines PEER, MOLT-4, HSB and YT.
Cellular Localization: Cell membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-vipr1_polyclonal_antibody-29976.html
Manual Link: https://www.elabscience.com/viewpdf-29976-elabscience-E-AB-33651.PDF