CD101 Polyclonal Antibody

Supplier: Elabscience Product Type: Antibody Clonality: Polyclonal Descritpion: Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4+ CD56+ leukemic tumor cells. Research Areas: Immunology Applications: WB,ELISA Recommended Dilutions: WB 1:500-1:2000, ELISA 1:10000 Size: 200 uL Concentration: 1mg/mL Swissprot: Q93033 Gene Accession: Reactivity: Human Host: Rabbit Isotype: IgG Immunogen: Synthesized peptide derived from the Internal region of human CD101. Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4. Purification: Affinity purification Conjugation: Unconjugated Calculated MW: 115kDa Tissue Specificity/Positive Control: Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4⁺ CD56⁺ blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients. Cellular Localization: Cell Membrane Storage: Store at -20C. Avoid freeze / thaw cycles. Product Link: https://www.elabscience.com/p-cd101_polyclonal_antibody-30002.html Manual Link: https://www.elabscience.com/viewpdf-30002-elabscience-E-AB-33677.PDF