GDF6 Polyclonal AntibodyE-AB-33730
Product Type: Antibody
Descritpion: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene are associated with Klippel-Feil syndrome, microphthalmia, and Leber congenital amaurosis.GDF6 (Growth Differentiation Factor 6) is a Protein Coding gene. Diseases associated with GDF6 include Microphthalmia, Isolated 4 and Klippel-Feil Syndrome 1, Autosomal Dominant. Among its related pathways are GPCR Pathway and Phospholipase-C Pathway. GO annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is GDF7.
Research Areas: Neuroscience, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:10000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human GDF-6.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 51kDa
Tissue Specificity/Positive Control:
Cellular Localization: Secreted
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-gdf6_polyclonal_antibody-30055.html
Manual Link: https://www.elabscience.com/viewpdf-30055-elabscience-E-AB-33730.PDF