Product Type: Antibody
Descritpion: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.
Research Areas: Cancer, Cardiovascular, Metabolism, Signal transduction, Stem cells
Recommended Dilutions: WB 1:1000-2000, IHC 1:50-1:200
Size: 200 uL
Immunogen: Recombinant Protein
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.4
Purification: Affinity purification
Tissue Specificity/Positive Control: Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Co-localizes with ASPN in chondrocytes within OA lesions of articular cartilage.
Cellular Localization: Secreted>extracellular space>extracellular matrix.
Storage: Store at -20C. Avoid freeze / thaw cycles.