BEST1 Polyclonal AntibodyE-AB-33760
Product Type: Antibody
Descritpion: This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.
Research Areas: Cancer, Neuroscience
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300 ELISA 1:40000
Size: 200 uL
Immunogen: Synthetic Peptide
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.4
Purification: Affinity purification
Tissue Specificity/Positive Control: Predominantly expressed in the basolateral membrane of the retinal pigment epithelium.
Cellular Localization: Cell membrane. Basolateral cell membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-best1_polyclonal_antibody-41191.html
Manual Link: https://www.elabscience.com/viewpdf-41191-elabscience-E-AB-33760.PDF