Product Type: Antibody
Descritpion: Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.
Research Areas: Cell Biology, Neuroscience, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300 ELISA 1:40000
Size: 200 uL
Immunogen: Synthetic Peptide
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.4
Purification: Affinity purification
Tissue Specificity/Positive Control: Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain.
Cellular Localization: Membrane. Colocalizes with CACNA1A in lipid raft fractions.
Storage: Store at -20C. Avoid freeze / thaw cycles.