CACNA1H Polyclonal AntibodyE-AB-33763
Product Type: Antibody
Descritpion: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Research Areas: Neuroscience, Signal transduction
Recommended Dilutions: IHC 1:50-100
Size: 200 uL
Immunogen: Synthetic Peptide
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Tissue Specificity/Positive Control: Expressed in kidney, liver, heart, brain. Isoform 2 seems to be testis-specific.
Cellular Localization: Membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-cacna1h_polyclonal_antibody-41204.html
Manual Link: https://www.elabscience.com/viewpdf-41204-elabscience-E-AB-33763.PDF