GABAA Receptor alpha4 Polyclonal Antibody
GABAA Receptor alpha4 Polyclonal Antibody

GABAA Receptor alpha4 Polyclonal Antibody

E-AB-33765

Regular price $399.00 $349.00 You Pay

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.GABRA4 (Gamma-Aminobutyric Acid Type A Receptor Alpha4 Subunit) is a Protein Coding gene. Diseases associated with GABRA4 include Status Epilepticus and Autism Spectrum Disorder. Among its related pathways are Ligand-gated ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include chloride channel activity and GABA-A receptor activity. An important paralog of this gene is GABRA6.
Research Areas: Neuroscience
Applications: WB,IHC-p
Recommended Dilutions: WB 1:1000-2000, IHC 1:100-200
Size: 200 uL
Concentration: 1mg/mL
Swissprot: P48169
Gene Accession:
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Synthetic Peptide
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW:
Tissue Specificity/Positive Control:
Cellular Localization: Cell junction>synapse>postsynaptic cell membrane. Cell membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-gabaa_receptor_alpha4_polyclonal_antibody-41208.html
Manual Link: https://www.elabscience.com/viewpdf-41208-elabscience-E-AB-33765.PDF