Phospho-MDM2 (Tyr394) Polyclonal AntibodyE-AB-51044
Product Category: Phospho/Acetyl/Methyl
Description: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Size: 200 uL
Recommended Dilutions: WB 1:500-2000, ELISA 1:10000-20000
Gene ID: 4193
Immunogen: Synthetic peptide from human protein
Formulation: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Purification: Affinity purification
Observed MW: 42kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Nucleus>nucleoplasm. Cytoplasm. Nucleus>nucleolus. Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus.
Product Link: https://www.elabscience.com/p-phospho_mdm2_(tyr394)_polyclonal_antibody-42213.html
Manaul Link: https://www.elabscience.com/viewpdf-42213-elabscience-E-AB-51044.PDF