Mouse Monoclonal Antibody to IL-10

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Interleukine 10 (IL-10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down- regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 3C12C12;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human IL-10 expressed in E. Coli.
Formulation: Purified antibody in PBS containing 0.03% sodium azide.
MW: N/A
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=42
Reference: 1. Vieira P, et al. PNAS, 1991.88:1172-1176.

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