Mouse Monoclonal Antibody to KSHV ORF45

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: KSHV
Clone: 2D4A5;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of KSHV ORF45 expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: N/A
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=47
Reference: 1. Chang Y. et al. 1994. Science. 266:1865-1869. ; 2. Zhu FX. et al. 2002. PNAS. 99: 5573-5578. ; 3. Zhu FX. et al. J Virol. 2003. April (77): 4221-4230. ;

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